By W. N. Aldridge (eds.)
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Additional info for A Symposium on Mechanisms of Toxicity
W. Kluivers and Mr. R. A. P. Vanwersch for enthusiastic and effective technical support. If (Sittingbourne) The effects of perfusion of isolated hearts with increasing concentrations ofDFP on mV, heart rate and contractile force are obviously dose-related. Have you actually measured heart cholinesterase activity and related percent inhibition to % reduction of mV, heart rate and contractile force parameters? You do not believe these effects to be due directly to inhibition of cholinesterase by D FP as oximes which normally reactivate alkylphosphorylated enzyme do not reduce its effects.
Of mean. 33 Anticholinesterases in Hypothermia 36·5° and 37·5°C and the tail temperature approximately 1oc above the room temperature. Recently it was found (Meeter, 1969) that if such an animal is injected with a suitable dose of an anti-ChE, the tail temperature responds by rising to 30°C or higher, whereas other areas of the skin remain completely passive, that is to say their temperature only drops with the body temperature. In the rats used in these experiments (female Glaxos, 180-220 g body weight) this tail response usually coincided exactly with the onset of the hypothermia.
Meeter (Rijswijk) We have done experiments at elevated environmental temperatures, in order to see if the hypothermia following ChE injection could be prevented. In fact, if the rats are kept at about 33°C during the first 5 h 40 E. Meeter following the ChE administration, the development of hypothermia is prevented. Higher environmental temperatures have not been used. Pepeu ( Cagliari) From your experiments it appears that the tail in the rat works like a radiator. I wonder what happens to temperature regulation if you remove the tail.
A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)