By S. González-Moreno
This e-book reports present learn in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the most recent scientific trials. The publication covers the necessities of perioperative intraperitoneal chemotherapy and glossy histopathological review of peritoneal floor malignancy. The book’s historic viewpoint at the unfolding of recent wisdom issues the best way for destiny study. members contain top specialists, between them the pioneers who gave delivery to this new period in oncology.
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Extra info for Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research, Volume 169)
This may be useful for the classification of patients for suitable therapeutic trials. 3 Clinical Implications and Significance fi of a Positive Cytology The prognosis of patients with potentially curable gastric cancer and intraperitoneal free cancer cells (P0Cy1) is very poor, because almost all patients with P0Cy1 status die 3 years after gastrectomy because of peritoneal recurrence. Simple gastrectomy without additional lymphadenectomy is the optimal strategy for the treatment . Chemotherapy regimens like intravenous 5-fluorouracil (5-FU) infusion  alone or in combination with other anticancer drugs (FAM , FAMTX ) have been used for these patients.
Total assay time to obtain the results is significantly shorter than that with the conventional RT-PCR. This assay system can detect reliably a minimum of 10 cancer cells . However, some false-positive results, which may be attributable to CEA-expressing noncancerous cells, have been encountered. In addition, this system is expensive and time-consuming. Yonemura et al. reported that the CEA RT-PCR assay yielded 40/230 (17%) positives, which included none of 26 patients with benign disease. The incidence of a positive cytology and a positive CEA level in peritoneal wash fluid was 19% and 15%, respectively.
Weiss L (1990) Metastatic inefficiency. Adv Cancer Res 54:159–211 9. Yonemura YC et al. (1997) A possible role of cytokines in the formation of peritoneal dissemination. Int J Oncol 111:349–358D 10. Yonemura Y (1998) Mechanisms of the formation of peritoneal dissemination. In: Yonemura Y, Shoten M (eds) Peritoneal dissemination. Kanazawa, pp 1–46 11. Kawamura T, Endo Y, Yonemura Y et al. (2001) Significance of integrin alpha2/beta1 in peritoneal dissemination of a human gastric cancer xenograft model.
Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research, Volume 169) by S. González-Moreno