By J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle
Every one quantity of Advances in Pharmacology presents a wealthy number of stories on well timed subject matters. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.
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B. Superantigen Presentation Results in Immune Cell Stimulation In addition to the a and P chains, the TCR contains a complex of four proteins, termed CD3, that are responsible for transducing signals to the cell upon binding to antigen. Of these four proteins, the [chain is thought to be responsible for signaling (Janeway and Travers, 1994). When traditional antigens or superantigens are presented by APCs and bind to the TCR, activation of a number of tyrosine kinases occurs in the responding T cell.
Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55, 3785-3789. Schreinemachers, D. , and Everson, R. B. (1994). Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5, 138-146. , and Smith, W. L. (1992). Prostaglandin endoperoxide synthase. The aspirin acetylation region. J. Biol. Chem. 267, 12387-12392. Smith, W. , and Marnett, L. J. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochim. Biophys. Acta 1083, 1-17.
Beauchamp, D. , DeBois, R. , and Falck, J. R. The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H 2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry 34, 3325-3337. DuBois, R. N. Nonsteroidal anti-inflammatory drug use and sporadic colorectal adenomas. Gastroenterology 108, 1310-1 314. DuBois, R. , Awad, J. , and Lanahan, A. (1994). Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells.
Advances in Pharmacology, Vol. 39 by J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle