Alcohol And the Gastrointestinal Tract: Special Issue: - download pdf or read online

By M. V. Singer, D. Brenner

ISBN-10: 3805580304

ISBN-13: 9783805580304

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Additional info for Alcohol And the Gastrointestinal Tract: Special Issue: Digestive Diseases 2005

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Slightly increased number of mitotic figures. Maier et al. [63] also looked at the effects of chronic ethanol consumption on the oral mucosa in a rat animal model. They observed a significant increase in the size of the basal cell layer and basal cell nuclei of oral epithelium and an increase in the percentage of cells in the S-phase of the cell cycle. The mean epithelial thickness was reduced. They suggested that the chronic ethanol consumption caused oral mucosal atrophy with associated hyper-regeneration, which in turn may result in an enhanced susceptibility of the mucosal epithelium towards chemical carcinogens.

Alcoholics, by definition, are addicted to excessive use of alcohol. Their cancer mortality and incidence rates have been studied in several countries and compared with the prevailing rates in the general population [38]. A 3- to 6-fold increased risk of head and neck cancer compared with the general population was reported for these alcoholics, the risk tended to be higher for oral and pharyngeal cancers than for laryngeal cancer. Cohort studies, looking at alcoholics in Norway, Sweden, Canada and the USA, have found an increased risk for oral cancer compared with the general population [7, 25].

Moreover, in vivo salivary acetaldehyde levels correlate very significantly with the levels that are produced in vitro. This offers the opportunity to use the in vitro salivary test as a tool to investigate possible variables which might influence salivary acetaldehyde production. Salivary acetaldehyde levels after ethanol intake strikingly exceed those known to be derived from endogenous metabolism of ethanol [85]. Via normal distribution and evaporation, salivary acetaldehyde may reach all target tissues of the upper aerodigestive tract.

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Alcohol And the Gastrointestinal Tract: Special Issue: Digestive Diseases 2005 by M. V. Singer, D. Brenner


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